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CrettolS.PetrovicN.MurrayM.2010Pharmacogenetics of phase I and phase II drug metabolism.162(2010),204219,1381-6128 25

staggered titration Cycle driver GI tolerance sets the pace Retatrutide Loading 2 mg 4 mg 8 mg (weeks 1-12) Frequency Once weekly Maintenance 12 mg weekly Route SubQ Cagrilintide Loading Start Week 9: 0.25 0.5 1.0 1.7 mg Frequency Once weekly Maintenance 2.4 mg weekly Route SubQ Weekly Schedule Example (Maintenance Phase) Monday Retatrutide 12 mg (one site) + Cagrilintide 2.4 mg (different site) Tuesday No injections Wednesday No injections Thursday No injections Friday No injections Saturday No injections Sunday No injections Both compounds are once-weekly

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Via that study, they discovered a common polymorphism in an important gene for health and well-being

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